Pharmaceutical Properties of Jelly Dosage Form Containing Calcium Polystyrene Sulfonate

Ando Masaki, Kouzaki Toshiyuki, Higuchi Fumio, Ichihashi Takanori, Takeda Motohiro, Mizutani Yuka, Uesaka Hiroshi

doi:10.14843/jpstj.60.261

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Other Title

ポリスチレンスルホン酸カルシウムを含有するゼリー状製剤に関する検討

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Description

<p>To reduce the gritty feeling of orally administered calcium polystyrene sulfonate powder (PS-Ca), we have developed a jelly dosage form containing PS-Ca. The jelly form (PS-Ca jelly), containing gelatin, carrageenan, and pectin, was confirmed to show a less gritty feeling when it was evaluated by the human volunteer's sensory test. Moreover, these additives seemed to regulate its adhesiveness and cohesiveness. In vitro potassium exchange profiles of PS-Ca jelly obtained by the press-through method and the paddle bead method showed no difference between PS-Ca jelly and PS-Ca powder (Kalimate^®), which was selected as a reference dosage form. A bioequivalence test of these forms was also performed with measuring serum potassium concentration changes, using nephrectomized rats. No statistically significant difference was found. The physical appearance of PS-Ca jelly stored at 60°C for 28 days remained unchanged, and the loss of water was within 2%. We have concluded that the newly formulated PS-Ca jelly will be able to contribute to the improvement of a patient's QOL.</p>

Journal

Journal of Pharmaceutical Science and Technology, Japan

Journal of Pharmaceutical Science and Technology, Japan 60 (4), 261-270, 2000

The Academy of Pharmaceutical Science and Technology, Japan

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Details 詳細情報について

CRID: 1390564238091941632

NII Article ID: 10013264769

NII Book ID: AN00266708

DOI: 10.14843/jpstj.60.261

ISSN: 21883149; 03727629

Web Site: https://search.jamas.or.jp/link/ui/2001095591

Text Lang: ja

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JaLC
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