Antibiotics Treatment for Cardiac Sarcoidosis: J-ACNES trial

  • Kusano Kengo
    Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
  • Tahara Nobuhiro
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine
  • Ishibashi Kohei
    Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
  • Asakura Masanori
    Division of Cardiovascular, Department of Internal Medicine, Hyogo College of Medicine
  • Nakamura Kazufumi
    Department of Cardiovascular Medicine, Okayama University
  • Takaya Yoichi
    Department of Cardiovascular Medicine, Okayama University
  • Sakamoto Naka
    Department of Cardiology, Asahikawa Medical University
  • Nakamura Tomohisa
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine
  • Noguchi Teruo
    Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
  • Yasuda Satoshi
    Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
  • Yazaki Yoshikazu
    Department of Cardiology, Advanced Care Center, Saku Central Hospital
  • Anzai Toshihisa
    Department of Cardiovascular Medicine, Hokkaido University
  • Yamaguchi Tetsuo
    Shinjuku Kaijo Bldg. Clinic
  • Asakura Koko
    Department of Data Science, National Cerebral and Cardiovascular Center
  • Hamasaki Toshimitsu
    Department of Data Science, National Cerebral and Cardiovascular Center
  • Terasaki Fumio
    Department of Cardiology/Medical Education Center, Osaka Medical College
  • Eishi Yoshinobu
    Department of Human Pathology, Graduate School of Medical Sciences, Tokyo Medical and Dental University

Bibliographic Information

Other Title
  • 心臓サルコイドーシスに対する抗菌薬治療:J-ACNES研究
  • シンゾウ サルコイドーシス ニ タイスル コウキンヤク チリョウ : J-ACNES ケンキュウ

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Abstract

<p>心臓サルコイドーシスでは,副腎皮質ステロイドなどの免疫抑制薬を終生内服することが必要とされている.しかし長期のステロイド内服による副作用の懸念,経過中にステロイド増量が必要であった例が約2割に上ることも報告され,根本的な治療が望まれている.サルコイドーシスの原因としてアクネ菌の関与が報告されており,抗菌薬(クラリスロマイシンとドキシサイクリン併用)を用いた前向き探索研究(J-ACNES研究)を開始した.</p>

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