Serum high–molecular–weight phosphorylated neurofilament (NF–H) as a biomarker in traumatic brain injury

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  • Shishido Hajime
    Emergency Medical Center, Kagawa University Hospital Department of Neurosurgery, Kagawa University Hospital
  • Irie Keiichirou
    Emergency Medical Center, Kagawa University Hospital Department of Neurosurgery, Kagawa University Hospital
  • Okazaki Tomoya
    Emergency Medical Center, Kagawa University Hospital
  • Hamaya Hideyuki
    Emergency Medical Center, Kagawa University Hospital
  • Shinohaya Natsuyo
    Emergency Medical Center, Kagawa University Hospital
  • Abe Yuko
    Emergency Medical Center, Kagawa University Hospital
  • Hifumi Toru
    Emergency Medical Center, Kagawa University Hospital
  • Kawakita Kenya
    Emergency Medical Center, Kagawa University Hospital Department of Neurosurgery, Kagawa University Hospital
  • Tamiya Takashi
    Department of Neurosurgery, Kagawa University Hospital
  • Kuroda Yasuhiro
    Emergency Medical Center, Kagawa University Hospital

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Other Title
  • 頭部外傷患者における血清リン酸化ニューロフィラメント（pNF‒H）の有用性の検討
  • 頭部外傷患者における血清リン酸化ニューロフィラメント(pNF-H)の有用性の検討
  • トウブ ガイショウ カンジャ ニ オケル ケッセイ リンサンカ ニューロフィラメント(pNF-H)ノ ユウヨウセイ ノ ケントウ

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Abstract

<p>  Traumatic brain injury (TBI) is a common health problem worldwide, with significant long‒term mortality and morbidity. A TBI causes diffuse axonal injury at the injured brain, and it can examined by several imaging techniques. An association between outcomes and several abnormal images in TBI patients has been recognized, but the efficacy of serum biomarkers of axonal injury remains unclear. High‒molecular‒weight phosphorylated neurofilament (pNF‒H) is a novel biomarker of axonal injury. Several studies showed that the blood level of pNF‒H is a predictive biomarker for outcomes in patients who have incurred a TBI. Here we investigated the association between the serum level of pNF‒H and the abnormality at diffusion weighted magnetic resonance imaging (DW‒MRI) in TBI. We retrospective analyzed the records of 14 patients who were admitted to our hospital with a TBI between July 2015 and July 2016. All patients in whom brain damage was detected underwent CT scans. Serum samples were collected at Days 0 and 3 post‒TBI. DW‒MRI was performed post‒injury in all patients. The serum level of pNF‒H was detected in five patients and was strongly correlated with an abnormality shown by DW‒MRI (71% sensitivity, 100% specificity). The results of our analyses demonstrated the serum pNF‒H at Day 3 post‒injury is a significant biomarker for detecting brain injury after a TBI.</p>

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