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A case of Miller Fisher syndrome with a false-positive edrophonium test
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- Yonemoto Kosuke
- Department of Neurology, National Hospital Organization Kanazawa Medical Center
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- Nomura Shunichi
- Department of Neurology, National Hospital Organization Kanazawa Medical Center
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- Shimizu Ai
- Department of Neurology, Kanazawa University School of Medicine
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- Sakajiri Kenichi
- Department of Neurology, National Hospital Organization Kanazawa Medical Center
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- Nitta Eishun
- Department of Neurology, National Hospital Organization Kanazawa Medical Center
Bibliographic Information
- Other Title
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- エドロホニウムテスト偽陽性であったMiller Fisher症候群の1例
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Description
<p>A 69-year-old woman presented with acute bilateral ptosis, ophthalmoplegia, ataxia, and hyporeflexia in the extremities following an antecedent upper respiratory infection. We suspected that she had Miller Fisher syndrome (MFS) and performed an edrophonium test (ET) to rule out myasthenia gravis (MG). Edrophonium chloride improved the patient’s bilateral ptosis, but not her ophthalmoplegia. Given the absence of the waning phenomenon on electrophysiological examination, the anti-acetylcholine receptor antibody, and a diurnal variation of symptoms, we concluded that the ET result was a false-positive. A diagnosis of MFS was confirmed by the presence of a positive anti-GQ1b antibody. To our knowledge, this is the first case report of MFS with a false-positive ET.</p>
Journal
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- Rinsho Shinkeigaku
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Rinsho Shinkeigaku 59 (6), 345-348, 2019
Societas Neurologica Japonica
