The use of oxycodone to treat dyspnea in terminally ill hemodialysis patients: a retrospective examination of seven cases

Awaya Makiko, Kato Shuichi, Kanou Kei, Watanabe Yusuke, Okada Hirokazu, Sukigara Minoru

doi:10.4009/jsdt.52.343

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終末期血液透析患者の呼吸困難に対するオキシコドンの有効性と安全性 : 7症例の検討
シュウマツキケツエキトウセキカンジャノコキュウコンナンニタイスルオキシコドンノユウコウセイトアンゼンセイ : 7 ショウレイノケントウ

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<p>Dyspnea is a common and distressing symptom, which is sometimes observed in terminally ill hemodialysis patients. Oxycodone is widely used to alleviate dyspnea in patients without renal dysfunction. However, in patients with renal failure, oxycodone use is avoided owing to concerns regarding the adverse effects associated with the accumulation of oxycodone. In this case series, we examined the usefulness and safety of oxycodone for ameliorating dyspnea in 7 terminally ill hemodialysis patients. Oxycodone was administered either orally or via a continuous subcutaneous infusion at a mean dose of 3.8 mg/day, and the dose was gradually increased as needed. We used the Japanese version of the Support Team Assessment Schedule (STAS-J) to quantitatively evaluate dyspnea. The STAS-J-based evaluations indicated that oxycodone significantly ameliorated dyspnea. No adverse events, such as respiratory depression, were reported in any patient. In conclusion, oxycodone can be safely used (following dose adjustments) to ameliorate dyspnea in patients undergoing hemodialysis.</p>

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Nihon Toseki Igakkai Zasshi

Nihon Toseki Igakkai Zasshi 52 (6), 343-348, 2019

The Japanese Society for Dialysis Therapy

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