Cancer predisposition in inherited bone marrow failure syndromes and primary immunodeficiency diseases

DOI Web Site PubMed
  • ISHIMURA Masataka
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University
  • OHGA Shouichi
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University

Bibliographic Information

Other Title
  • 先天性骨髄不全症候群と原発性免疫不全症におけるがん素因
  • センテンセイ コツズイ フゼン ショウコウグン ト ゲンパツセイ メンエキ フゼンショウ ニ オケル ガン ソイン

Search this article

Description

<p>Inherited bone marrow failure syndromes (IBMFS) are caused by mutations in genes associated with DNA repair and telomere maintenance. In addition, mutations in ribosome-related genes cause defective hematopoiesis. Patients with IBMFS exhibit a predisposition to developing hematological malignancy or solid tumor because of the defect in cellular and molecular hemostasis. The SAMD9 mutation causes the multisystem disorder, MIRAGE syndrome, characterized by congenital adrenal hypoplasia and loss of chromosome 7, providing a novel insight into the correlation between the germline and somatic mutations of SAMD9/SAMD9L and myelodysplastic syndrome (MDS) with monosomy 7. Primary immunodeficiency diseases (PID) are caused by inborn errors of the immune system. PID patients with inadequate tumor immunity are at an elevated risk of developing malignancies such as lymphoma, leukemia, and gastrointestinal cancer. Recently, monocytopenia and mycobacterial infection (MonoMAC) syndrome with the GATA2 gene mutation have been reported as PID related to bone marrow failure. Patients with MonoMAC syndrome often develop MDS and acute myeloid leukemia. Here, we present the pediatric-onset IBMFS and/or PID with cancer predisposition and briefly discuss the tumorigenesis in each monogenic disease.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 60 (6), 702-707, 2019

    The Japanese Society of Hematology

Keywords

Details 詳細情報について

Report a problem

Back to top