Sarilumab is effective rapidly in ultrasound for patients with rheumatoid arthritis

DOI
  • Kimura Yuko
    Arisawa General Hospital Department of Immuno-Rheumatology Center
  • Yoshida Shuzo
    Arisawa General Hospital Department of Immuno-Rheumatology Center

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  • 生物学的製剤効果不十分例におけるサリルマブ5例の短期的治療効果

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<p>  Objective: The purpose of this study was to examine short-term efficacy of sarilumab therapy in patients with rheumatoid arthritis（RA）.</p><p>  Subjects and methods: Five patients with RA who underwent sarilumab treatment were assessed. 200 mg of sarilumab was administered SC by subcutaneous injection every 2 weeks for 12 weeks to patients with RA. Disease activity of RA was examined by DAS28-ESR and ultrasonography.</p><p>  Results: All patients were women（mean age 64.0 ± 17.8, mean disease duration 16.5 ± 14.0 years）. DAS28-ESR was significantly improved（4.58 ± 0.65 at baseline to 2.90 ± 0.76 at 12 weeks p= 0.03）. Total power Doppler score was also significantly improved（10.6 ± 2.2 at baseline to 2.0 ± 1.9 at 12 weeks p= 0.0067）.</p><p>  Conclusions: These findings suggested that sarilumab may lead to rapid improvement assessed by DAS28-ESR and ultrasound in patients with rheumatoid arthritis.</p>

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