Preoperative Administration of Branched-chain Amino Acids Improves Prognosis After Hepatectomy in Middle-aged Rats with Diabetes Mellitus

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  • Wakana Noriaki
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • Todoroki Kikue
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • Yamazaki Yuko
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • Wakana Mami
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • Homma Kazuhiro
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • Tanaka Etsuro
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • Fukuyama Naoto
    Department of Physiology, Tokai University School of Medicine

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  • 分岐鎖アミノ酸の術前投与は中年期糖尿病ラットにおける肝切除術後の予後を改善する

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Abstract

<p>The prognosis of elderly patients with hepatocellular carcinoma and concurrent diabetes mellitus (DM) who require hepatectomy is poor because of their high risk of postoperative liver failure. Although the effectiveness of perioperative administration of branched-chain amino acids (BCAA) has been previously reported, its effectiveness in elderly patients with DM remains unclear. In this study, we examined the effect of preoperative administration of BCAA in middle-aged hepactomized rats with DM. A total of 22 middle-aged male Fischer 344 rats were treated with streptozotocin to induce DM and were randomly divided into two groups : 11 rats received BCAA solution and 11 rats received water for 7 days prior to surgery. Two-thirds hepatectomy was performed in all rats. The survival rate, body weight reduction rate, blood sample data (blood sugar, aspartate aminotransferase, alanine aminotransferase, endotoxin, tumor necrosis factor-α, and interleukin-6), and the bromodeoxyuridine labeling index were evaluated 48 h post-surgery. The survival rate of the BCAA group was significantly higher than that of the control group (91 vs. 54%). The rate of body weight reduction in the BCAA group was significantly lower than that in the control group 48 h after hepatectomy (9.2±2.7 vs. 13.0±3.7%, means±SD). No significant differences in blood sample data, resected liver weight, or remnant liver weight were observed between the two groups. The bromodeoxyuridine labeling index in the BCAA group was significantly higher than that in the control group (14.5±1.7 vs. 11.7±0.8%, means±SD). The present study demonstrated that preoperative administration of BCAA improved postoperative prognosis in middle-aged hepactomized rats with DM.</p>

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