Usefulness of Liposomal Neuroprotectants for the Treatment of Ischemic Stroke

DOI Web Site Web Site 18 References
  • FUKUTA Tatsuya
    Department of Medical Biochemistry, University of Shizuoka Graduate School of Pharmaceutical Sciences
  • ASAI Tomohiro
    Department of Medical Biochemistry, University of Shizuoka Graduate School of Pharmaceutical Sciences
  • OKU Naoto
    Department of Medical Biochemistry, University of Shizuoka Graduate School of Pharmaceutical Sciences

Bibliographic Information

Other Title
  • 脳梗塞治療におけるリポソームDDS製剤の有用性
  • ノウ コウソク チリョウ ニ オケル リポソーム DDS セイザイ ノ ユウヨウセイ

Search this article

Abstract

<p>Ischemic stroke is a leading cause of severe disability and death in the world. Tissue plasminogen activator (t-PA) for thrombolytic therapy is the only approved therapeutic agent worldwide for acute ischemic stroke. However, patients received t-PA therapy are extremely limited due to the narrow therapeutic time window (TTW) and the risk of cerebral hemorrhage. In addition, cerebral ischemia/reperfusion (I/R) injury is a serious problem for the patient’s prognosis. Hence, development of more effective therapies has been most desirable. As a distinctive phenomenon after an ischemic stroke, it has been reported that vascular permeability of the blood-brain barrier (BBB) is increased around the ischemic region. Our previous studies revealed that nano-sized liposomes can accumulate in the ischemic region via the disintegrated BBB and that liposomal delivery of neuroprotective agents should be effective for the treatment of cerebral I/R injury. In addition, our recent study demonstrated that combination treatment with liposomal neuroprotectants and t-PA could suppress the deleterious effects of t-PA and prolong its TTW in an ischemic stroke model rat prepared by the photochemically induced thrombosis method. In this review, we introduce our recent findings on ischemic stroke therapy by using liposomal drug delivery systems.</p>

Journal

  • Oleoscience

    Oleoscience 17 (8), 359-366, 2017

    Japan Oil Chemists' Society

References(18)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top