A rat model of serous borderline ovarian tumors induced by 7,12-dimethylbenz[a]anthracene

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  • Cai Song-Qi
    Department of Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xvhui District, Shanghai 200032, China Department of Radiology, Jinshan Hospital, Shanghai Medical College, Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China
  • Li Ying
    Department of Radiology, Jinshan Hospital, Shanghai Medical College, Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China
  • Li Yong-Ai
    Department of Radiology, Jinshan Hospital, Shanghai Medical College, Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China
  • Wang Li
    Department of Pathology, Jinshan Hospital, Shanghai Medical College, Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China
  • Zhu Jian
    Department of Ultrasound, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Wenzhou, Zhejiang 325003, China
  • Zhao Shu-Hui
    Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University, No. 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China
  • Li Xin
    Department of Radiology, Jinshan Hospital, Shanghai Medical College, Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China
  • Qiang Jin-Wei
    Department of Radiology, Jinshan Hospital, Shanghai Medical College, Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China

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<p>Serous borderline ovarian tumors (SBOTs) behave between benign cystadenomas and carcinomas, and the effective detection and clinical management of SBOTs remain clinical challenges. Because it is difficult to isolate and enrich borderline tumor cells, a borderline animal model is in need. 7,12-dimethylbenz[a]anthracene (DMBA) is capable of inducing the initiation, promotion, and progression of serous ovarian tumors. This study aims to investigate the proper dosage and induction time of DMBA for rat models of SBOTs, and explore their morphological features demonstrated by magnetic resonance (MR) imaging and molecular genetic characteristics. Rats were randomly divided into six groups (1 mg/70 D, 2 mg/70 D, 3 mg/70 D, 2 mg/50 D, 2 mg/90 D, and 2 mg/110 D). The 3 mg/70 D group induced the most SBOTs (50.0%, 12/24). The micropapillary projections were shown on MR imaging, which was the characteristic of SBOTs. The Cyclin D1 characterizing an early pathogenetic event strongly expressed in induced serous benign tumors (SBTs). The immunoreactivity staining scores of P53 expression significantly increased from SBTs, SBOTs to serous ovarian carcinomas (SCAs), which elucidate that P53 might be a promising biomarker to grade serous ovarian tumors. Based on morphological and molecular genetic similarities, this rodent SBOT model was suitable for investigating the pathogenesis of serous ovarian tumors and developing an early detection strategy.</p>

収録刊行物

  • Experimental Animals

    Experimental Animals 68 (3), 257-265, 2019

    公益社団法人 日本実験動物学会

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