A Case of Disseminated Cryptococcosis with Intracapillary Cryptococci in Pathological Imaging During Treatment of Lung Cancer and Dermatomyositis

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  • HINO Aoi
    Department of Respiratory Medicine, Chiba University Hospital
  • SHIMIZU Hidefumi
    Department of Respiratory Medicine, JCHO Tokyo Shinjuku Medical Center
  • SASAKI Atsushi
    Department of Respiratory Medicine, JCHO Tokyo Shinjuku Medical Center
  • KOJIMA Hiroshi
    Department of Respiratory Medicine, JCHO Tokyo Shinjuku Medical Center
  • HORIE Masahiro
    Department of Respiratory Medicine, JCHO Tokyo Shinjuku Medical Center
  • MIZOO Akira
    Department of Respiratory Medicine, JCHO Tokyo Shinjuku Medical Center

Bibliographic Information

Other Title
  • 皮膚筋炎先行の肺癌加療中に播種性クリプトコックス症による intracapillary cryptococci の病理像を呈した剖検例
  • 症例 皮膚筋炎先行の肺癌加療中に播種性クリプトコックス症によるintracapillary cryptococciの病理像を呈した剖検例
  • ショウレイ ヒフ キンエン センコウ ノ ハイガン カリョウ チュウ ニ ハシュセイ クリプトコックスショウ ニ ヨル intracapillary cryptococci ノ ビョウリゾウ オ テイシタ ボウケンレイ

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Abstract

<p>A 71-year-old woman who was being treated for dermatomyositis with a corticosteroid developed multiple lung nodules. A biopsy from the right middle lung lobe revealed a lung adenocarcinoma harboring the EGFR mutation. During chemotherapy with gefitinib, she suddenly presented with acute respiratory failure. Chest computed tomography did not reveal any abnormalities other than pulmonary nodules, which are signs of metastasis of lung cancer, so we could not determine the cause of respiratory failure. She died within four days after the onset of respiratory failure. An autopsy revealed pulmonary cryptococcosis consisting of multiple lung nodules and intracapillary cryptococci in multiple organs, in addition to the right middle lobe lung adenocarcinoma accompanied with bone metastasis. Intracapillary cryptococci are a rare pathological condition resulting from disseminated cryptococcosis. Intracapillary cryptococci could lead to acute respiratory failure by obstruction of pulmonary capillaries, and would be difficult to diagnose using computed tomography.</p>

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 93 (2), 139-142, 2019-03-20

    The Japanese Association for Infectious Diseases

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