Erythema Elevatum Diutinum Treated With Nicotinamide

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  • ニコチン酸アミドが奏効した持久性隆起性紅斑の 1 例

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Abstract

<p>A 78-year-old woman developed asymptomatic erythema on the right knee 1 year ago. She received antibiotic therapy, but it was unsuccessful. At the initial visit, she exhibited elevated indurated erythema with nodules on the lateral side of her right knee. Skin biopsy from the nodule demonstrated leukocytoclastic vasculitis with dense neutrophilic cell inltration into the dermis. Based on the clinical and histopathological ndings, the diagnosis of erythema elevatum diutinum (EED) was made. Dapsone (DDS) at 50 mg/day orally was started, but she discontinued it due to side effects. We tried nicotinamide at 200 mg/day orally and noted clearance of her skin lesion after 4 weeks. Dapsone is the rst-line therapy for EED, but it often causes mild to severe side effects. On the other hand, nicotinamide is a physiological nutrient and is therefore relatively safe to use. Nicotinamide therapy can be a promising option as a second-line treatment for EED when DDS cannot be used. Skin Research, 18 : 237-240, 2019 </p>

Journal

  • Hifu no kagaku

    Hifu no kagaku 18 (4), 237-240, 2019

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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