Trends in Serum Lipid Levels of a 10- and 13-Year-Old Population in Fukuroi City, Japan (2007–2017)

  • Kouda Katsuyasu
    Department of Hygiene and Public Health, Kansai Medical University
  • Iki Masayuki
    Department of Public Health, Kindai University Faculty of Medicine
  • Fujita Yuki
    Department of Public Health, Kindai University Faculty of Medicine
  • Nakamura Harunobu
    Department of Health Promotion and Education, Graduate School of Human Development and Environment, Kobe University
  • Ohara Kumiko
    Department of Health Promotion and Education, Graduate School of Human Development and Environment, Kobe University
  • Tachiki Takahiro
    Department of Public Health, Kindai University Faculty of Medicine
  • Nishiyama Toshimasa
    Department of Hygiene and Public Health, Kansai Medical University

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<p>Background: Current trends in serum lipid levels among children are likely to be important predictors of future cardiovascular disease prevalence. However, no studies have examined trends in low-density lipoprotein cholesterol (LDL-C) levels in Japanese children.</p><p>Methods: We investigated trends in LDL-C levels from 2008 through 2017 and HDL-C levels from 2007 through 2017 in a population of 10- and 13-year-old children in Fukuroi City, Japan. We analyzed 17,838 children, accounting for 93.8% of all fifth and eighth graders in the entire city. Adverse lipid levels were defined as follows: 130 mg/dL or higher for LDL-C, and lower than 40 mg/dL for HDL-C. The Jonckheere-Terpstra and Cochran-Armitage tests were used to evaluate secular trends in mean serum lipid levels and prevalence of dyslipidemia, respectively.</p><p>Results: There were no significant trends in BMI during the study period. In children aged 10 years, serum levels of LDL-C and HDL-C showed significant positive associations with calendar year during the study period for both sexes. A significant increase in HDL-C levels was observed in girls aged 13 years. On the other hand, no significant trends were observed in the prevalence of high LDL-C or low HDL-C regardless of sex or age, while the prevalence of high non-HDL-C showed a significant increase in boys.</p><p>Conclusions: In the Fukuroi population, serum levels of LDL-C and HDL-C slightly increased in both boys and girls aged 10 years, and HDL-C levels slightly increased in girls aged 13 years, during the past decade.</p>

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