A Case of Malignant Blue Nevus with An Amelanotic Region

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  • Habu Minako
    Department of Dermatology, Ehime University Graduate School of Medicine
  • Tohyama Mikiko
    Department of Dermatology, National Hospital Organization Shikoku Cancer Center
  • Oda Fumiko
    Oda urology・Fumiko dermatology clinic
  • Mori Hideki
    Department of Dermatology, Ehime University Graduate School of Medicine
  • Hashimoto Koji
    Ehime Prefectural University of Health Sciences
  • Saida Toshiaki
    Shinshu University
  • Sayama Koji
    Department of Dermatology, Ehime University Graduate School of Medicine

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Other Title
  • amelanotic領域を有したmalignant blue nevusの1例
  • 症例報告 amelanotic領域を有したmalignant blue nevusの1例
  • ショウレイ ホウコク amelanotic リョウイキ オ ユウシタ malignant blue nevus ノ 1レイ

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Abstract

<p>A 60-year-old Japanese woman presented with a blue macule associated with a black dome-shaped nodule and a red flat nodule on the right occiput. Histopathological examination of the red nodule revealed large atypical cells containing no melanin proliferated in the entire dermis and the subcutaneous tissue. Immunohistochemical samples were positive for HMB-45 and Melan-A. In contrast, in the black nodule, tumor cells containing abundant melanin granules densely proliferated throughout the entire dermis without atypia. We diagnosed a malignant blue nevus with an amelanotic region occurring on the cellular blue nevus. The patient died from lung and bone metastases 2 years after surgery.</p>

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