Effect of oral vitamin C ingestion on the vascular endothelial function and oxidative stress marker exposed to after transient heat-not-burn tobacco smoking

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  • Azuma Ayako
    Center for Faculty-wide General Education, Shikoku University Graduate School of Integrated Arts and Science, Tokushima University
  • Miura Hajime
    Laboratory for Applied Physiology, Faculty of Integrated Arts and Science, Tokushima University
  • Ishikawa Mizuki
    Graduate School of Integrated Arts and Science, Tokushima University
  • Tamura Yasuaki
    Graduate School of Integrated Arts and Science, Tokushima University

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  • ビタミンCの摂取が一過性の加熱式タバコ喫煙後の動脈機能および酸化ストレスマーカーに及ぼす影響
  • ビタミン C ノ セッシュ ガ イッカセイ ノ カネツシキ タバコ キツエン ゴ ノ ドウミャク キノウ オヨビ サンカ ストレスマーカー ニ オヨボス エイキョウ

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<p>Heat-not-burn (HNB) tobacco smoking has spread throughout the market. While it is suggested that HNB tobacco smoking reduces the vascular endothelial function and is associated with a high risk of developing cardiovascular disease. The antioxidant of vitamin C may attenuate the unfavorable effects of HNB tobacco smoking. In the present study, we examined the effect of oral vitamin C ingestion on the flow-mediated dilation (FMD) at the brachial artery and oxidative stress markers in patients before and after transient HNB tobacco smoking. Twelve healthy adult males underwent high-resolution ultrasonography of the brachial artery and evaluations of reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP) before and after a single session of HNB smoking. FMD was used to examine the endothelial function and the oxidative stress and antioxidant status were determined by using a FRES4 analyzer. In this randomized, crossover, controlled trial, measurements were performed on 2 different days 20 min after the oral administration of 1000 mg of ascorbic acid (VC trial) or a placebo (P trial). Although the FMD values decreased after a single HNB smoking session in both trials, the VC trial showed significantly higher values than the P trial at 60 and 120 min after smoking. Whereas the FMD values 120 min after smoking in the P trial were lower compared to the Pre values, there was no difference in the VC trial. These results suggested that the ingestion of vitamin C might suppress the decrease in the endothelial function caused by a single HNB smoking.</p>

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