Multivariate Analysis for Molecular Species of Cholesteryl Ester in the Human Serum

DOI PDF Web Site Web Site Web Site ほか1件をすべて表示 一部だけ表示 参考文献17件 オープンアクセス
  • CHEN Yifan
    Graduate School of Information Science and Technology, Hokkaido University
  • HUI Shu-Ping
    Faculty of Health Sciences, Hokkaido University
  • MIURA Yusuke
    Faculty of Health Sciences, Hokkaido University
  • KATO Sota
    Faculty of Health Sciences, Hokkaido University
  • SAKURAI Toshihiro
    Faculty of Health Sciences, Hokkaido University
  • CHEN Zhen
    Faculty of Health Sciences, Hokkaido University
  • OKADA Emiko
    Department of Nutritional Epidemiology and Shokuiku, National Institute of Biomedical Innovation, Health and Nutrition
  • UKAWA Shigekazu
    Graduate School of Human Life Science, Osaka City University
  • NAKAGAWA Takafumi
    The Hokkaido Centre for Family Medicine
  • NAKAMURA Koshi
    Department of Public Health and Hygiene, Graduate School of Medicine, University of the Ryukyus
  • TAMAKOSHI Akiko
    Department of Public Health, Faculty of Medicine, Hokkaido University
  • CHIBA Hitoshi
    Department of Nutrition, Sapporo University of Health Sciences
  • MINAMI Hiroyuki
    Information Initiative Center, Hokkaido University
  • MIZUTA Masahiro
    Information Initiative Center, Hokkaido University

この論文をさがす

説明

<p>Cholesteryl ester (CE) is an ester of cholesterol and fatty acid (FA). Plasma CE reflects complicated metabolisms of cholesterol, phospholipids, lipoproteins, and dietary FAs. An informatics approach could be useful for analysis of the CE species. In this study, two basic dimension reduction methods, principal component analysis (PCA) and factor analysis, were applied to serum CE species determined by LC-MS/MS in a Japanese population (n = 545). PCA and factor analysis both reflected the size (concentration), food source, fat solubility, and biological aspect of the CE species. In a comparison between PCA (PC4) and factor analysis (factor 4), the latter was found to be more suggestive from a biological aspect of n-6 FAs. Cholesteryl docosahexaenoate (DHA) was found to be unique by a factor analysis, possibly relevant to the unique accumulation of DHA in the brain. An informatics approach, especially factor analysis, might be useful for the analysis of complicated metabolism of CE species in the serum.</p>

収録刊行物

  • Analytical Sciences

    Analytical Sciences 36 (3), 373-378, 2020-03-10

    社団法人 日本分析化学会

参考文献 (17)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ