ABO BLOOD GROUP TYPING REACTIVITY TO CISAB IN A NEWBORN BABY AND DEVELOPMENTAL CHANGE IN ABO ANTIGEN LEVEL

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  • Sakurazawa Takayo
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Takahashi Shuichiro
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital Department of Hematology, Faculty of Medicine, Hokkaido University
  • Watanabe Chiaki
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Ito Makoto
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Uozumi Ryo
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Masuda Yuya
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Hayasaka Koji
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Nishida Mutsumi
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
  • Sugita Junichi
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital Department of Hematology, Faculty of Medicine, Hokkaido University
  • Teshima Takanori
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital Department of Hematology, Faculty of Medicine, Hokkaido University

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  • 新生児におけるcisAB型の血液型検査反応性と発育に伴う抗原量の変化に関する検討

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<p>ABO blood typing reactivity to cisA2B3 shows weak agglutination to anti-A, anti-B and anti-B antibody present in plasma. However, the reactivity of ABO to cis A2B3 in newborn babies remains to be elucidated. Here, we examined ABO blood typing reactivity and developmental change of A and B antigen levels in a boy with suspected cis A2B3. First, we checked his ABO blood typing with the column agglutination method on birth. Reactivity of anti-A was 2+, and anti-B was negative. On further ABO subtype tests, flow cytometric analysis (FCM) of antigen levels and ABO gene typing, we detected B antigens on his red blood cells by the adsorption-elution test. Expression levels of A and B antigens were lower than those of his mother. Both he and his mother's ABO gene type were defined as cisAB01/O01. As he grew, he showed higher B antigen levels and anti-B antibodies were detected at age 23 months. In infants with cisAB, B antigen levels are too low to be detected with usual ABO blood typing. ABO gene typing and FCM are therefore useful for ABO blood typing, particularly for newborn babies with suspected cisAB.</p>

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