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- Yamamoto Ayaha
- Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ.
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- Obana Masanori
- Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ.
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- Nakae Takafumi
- Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ.
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- Miyake Yoshiaki
- Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ.
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- Mitsuoka Sayuri
- Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ.
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- Maeda Makiko
- Education and Research Project for Pharm.D, Grad. Sch. Pharm., Osaka Univ.
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- Imaizumi Kazunori
- Department of Biochemistry, Grad. Sch. Biomed. & Health Sci., Hiroshima Univ.
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- Matsumoto Kotaro
- Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ.
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- Fujio Yasushi
- Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ.
Bibliographic Information
- Other Title
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- 転写因子OASISの阻害は腎線維化を抑制する
Abstract
<p>[Background] Since kidney fibrosis is a common pathway to many kidney diseases, prevention of kidney fibrosis could be a therapeutic strategy for kidney diseases. Previously, we reported that old astrocyte specifically induced substance (OASIS), a transcription factor, promotes proliferation of renal myofibroblasts, analyzed by in vitro assay. However, the pathophysiological significance of OASIS in kidney fibrosis in vivo remains to be elucidated.</p><p>[Methods/Results] C57BL/6J mice were subjected to unilateral ureteral obstruction (UUO) to cause kidney fibrosis, analyzed by Sirius red staining and hydroxyproline assay. AEBSF, an inhibitor of OASIS, suppressed kidney fibrosis at day 7 after UUO. Moreover, kidney fibrosis was ameliorated in OASIS KO mice compared with WT mice, accompanied by decreased proliferation of myofibroblasts. To explore the downstream of OASIS, DNA microarray was performed using myofibroblasts from OASIS KO mice. Interestingly, it was found that bone marrow stromal antigen 2 (BST2) was a candidate downstream gene of OASIS. Anti-BST2 antibody treatment attenuated UUO-induced kidney fibrosis.</p><p>[Conclusion] OASIS contributes to the develop of kidney fibrosis by promoting the proliferation of myofibroblasts, in part, through increased BST2 expression. OASIS could be a therapeutic target against kidney fibrosis.</p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 93 (0), 2-O-071-, 2020
Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390565134835990016
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- NII Article ID
- 130007811565
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed