書誌事項
- タイトル別名
-
- Elucidation of the serotonergic circuits involving in nicotine withdrawal symptoms by using optogenetics
抄録
<p>Abrupt tobacco cessation in chronic smokers causes various withdrawal symptoms including anxiety, depressed mood, decreased arousal, and irritability. Recent studies have shown that interpeduncular nucleus is involved in nicotine withdrawal symptoms and that the nucleus projects to serotonergic nuclei. Therefore we hypothesized that the central serotonergic system regulates some of nicotine withdrawal symptoms. To test this hypothesis, we used transgenic mice expressing archaerhodopsin (ArchT) in central serotonergic neurons only, and examined whether serotonergic inhibition could induce withdrawal symptoms. Mice drank water containing nicotine for 6 weeks, and receive mecamylamine injection to induce withdrawal symptoms. Withdrawal symptoms: somatic signs, anxiety-like behavior, and depressive-like behavior were measured by visual observation, an elevated plus maze test, and a forced swim test, respectively. Somatic sings were precipitated by mecamylamine following chronic nicotine drinking. Neither anxiety-like nor depressive-like behavior was affected by chronic nicotine drinking or mecamylamine. Central serotonergic inhibition induced somatic signs in mice received mecamylamine injection without chronic nicotine drinking.</p>
収録刊行物
-
- 日本薬理学会年会要旨集
-
日本薬理学会年会要旨集 92 (0), 3-P-046-, 2019
公益社団法人 日本薬理学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390565134837824896
-
- NII論文ID
- 130007813314
-
- ISSN
- 24354953
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可