Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety
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- Nagai Hirotaka
- Div. Pharmacol., Grad. Sch. Med., Kobe Univ.
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- Higashida Shu
- Div. Pharmacol., Grad. Sch. Med., Kobe Univ.
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- Nakayama Kazuki
- Div. Pharmacol., Grad. Sch. Med., Kobe Univ.
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- Shinohara Ryota
- Div. Pharmacol., Grad. Sch. Med., Kobe Univ.
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- Taniguchi Masayuki
- Div. Pharmacol., Grad. Sch. Med., Kobe Univ.
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- Nagai Midori
- Div. Pharmacol., Grad. Sch. Med., Kobe Univ.
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- Hikida Takatoshi
- Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka Univ.
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- Yawata Satoshi
- Dep. Biol. Sci., Grad. Scho. Med., Kyoto Univ.
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- Ago Yukio
- Lab. Biopharmaceutics, Grad. Scho. Pharm. Sci., Osaka Univ.
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- Kitaoka Shiho
- Div. Pharmacol., Grad. Sch. Med., Kobe Univ.
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- Narumiya Shuh
- Medical Innovation Center, Grad. Sch. Med., Kyoto Univ.
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- Furuyashiki Tomoyuki
- Div. Pharmacol., Grad. Sch. Med., Kobe Univ.
Bibliographic Information
- Other Title
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- マウスの社会挫折ストレスにより誘導される情動変容の多面的解析:社会忌避と不安亢進の解離
Abstract
<p>Repeated social defeat stress (R-SDS) induces multiple behavioral changes in mice. However, the relationships between these behavioral changes were not fully understood. In the first experiment, to examine how the social avoidance is related to R-SDS-impaired behavioral flexibility, 10-week-old male C57BL/6N mice received R-SDS followed by the social interaction test and the attentional set shifting task. R-SDS impaired attentional set shifting irrespective of the development of social avoidance. In the second experiment, to examine whether R-SDS affects sexual preference and how this behavioral change is related to the social avoidance and R-SDS-heightened anxiety, another group of 10-week-old male C57BL/6N mice were subjected to R-SDS followed by the social interaction test, the female encounter test and the elevated plus maze test. The anxiety was heightened in the defeated mice without social avoidance, but not in those which showed social avoidance. Furthermore, female preference was increased specifically in the defeated mice which showed heightened anxiety, but was not related to the level of social avoidance. Together, these results showed that attentional set shifting is more sensitive to R-SDS than social interaction, and that female preference is affected by R-SDS in association with heightened anxiety rather than the social avoidance.</p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 92 (0), 2-P-022-, 2019
Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390565134837964416
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- NII Article ID
- 130007813014
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed