Establishment of cardiac action potential recording using a membrane potential indicator in the mouse sinoatrial node
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- Toyama Yuichi
- Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
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- Yonekura Manabu
- Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
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- Arakawa Yoshiaki
- Department of Pharmacology, Hirosaki University Graduate School of Medicine
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- Higuchi Shoki
- Department of Pharmacology, Hirosaki University Graduate School of Medicine
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- Tomita Hirofumi
- Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
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- Murakami Agnieszka M.
- Department of Pharmacology, Hirosaki University Graduate School of Medicine
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- Itagaki Shirou
- Collaboration Center for Community and Industry, Sapporo Medical University, Sapporo
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- Murakami Manabu
- Department of Pharmacology, Hirosaki University Graduate School of Medicine
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The cardiac action potential in the sinoatrial node is important, as it propagates throughout the heart and determines cardiac rhythm. Because of the anatomical complexity, pacemaker cells in the sinoatrial node can be difficult to identify for electrophysiological analysis. Also, analysis of pacemaker cells requires a specialized technique. In this study, we tried to analyze pacemaking in the sinoatrial node. First, we evaluated the expression of various factors that participate in pacemaking or modify cardiac rhythm. Next, we evaluated recordings of the action potential in the sinoatrial node by a conventional electrophysiological technique and using oxonol V, a fluorescent voltage-sensitive dye.
収録刊行物
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- 弘前医学
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弘前医学 70 (2-4), 163-171, 2020
弘前大学大学院医学研究科・弘前医学会
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詳細情報 詳細情報について
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- CRID
- 1390565134841515264
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- NII論文ID
- 130007818304
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- NII書誌ID
- AN00211444
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- ISSN
- 24344656
- 04391721
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- HANDLE
- 10129/00006966
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- NDL書誌ID
- 030294090
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可