Villoglandular adenocarcinoma of uterine cervix during pregnancy

MATSUDA Yoko, MORISHITA Hajime, OIDA Kenji, SATO Hiroshi, TAGUCHI Nao, HIROSE Masaya

doi:10.11437/sanpunosinpo.72.8

<p>A favorable outcome can be obtained in the majority of cases of villoglandular adenocarcinoma (VGA), a rare subtype of adenocarcinoma that develops in the uterine cervix, though the prognosis of advanced cases is worse. We report experience with a case of VGA diagnosed during pregnancy. A 34-year-old nulliparous woman was referred to our hospital because of abnormal cervical cytology results indicating HSIL. We performed a colposcopy-directed biopsy, though nothing remarkable was revealed. The patient revisited our hospital six months later and was found to have a normal pregnancy at eight weeks of gestation, while abnormal cervical cytology results indicating HSIL were seen once again. In addition, colposcopic findings revealed a minute polypoid lesion with a diameter of approximately 2-3 mm in the cervix and directed biopsy results suggested an early stage VGA of the uterine cervix. We performed cervical conization and cerclage procedures at 15 weeks of gestation, and pathological findings revealed an intraepithelial VGA and HSIL of the uterine cervix, while the cut margin was negative. The pregnancy was continued with repeated cervical cytology examinations. The patient delivered a healthy newborn vaginally at 39 weeks of gestation. At 10 months after conization, there was no evidence of recurrence. [Adv Obstet Gynecol, 72 (1) : 8-13, 2020 (R2.2)]</p>

Villoglandular adenocarcinoma of uterine cervix during pregnancy

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