Fundamental study of “Lumipulse Presto IL-2R” reagent for measuring soluble interleukin-2 receptor with Lumipulse L2400

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  • WATANABE Kanako
    Department of Clinical Laboratory, Tottori University Hospital
  • NAKADA Yumeto
    Department of Clinical Laboratory, Tottori University Hospital
  • ICHIKAWA Hitomi
    Department of Clinical Laboratory, Tottori University Hospital
  • NOGAMI Satoshi
    Department of Clinical Laboratory, Tottori University Hospital
  • FUKUDA Tetsuya
    Department of Clinical Laboratory, Tottori University Hospital
  • MOTOKURA Toru
    Division of Clinical Laboratory Medicine, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine

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  • ルミパルスL2400における可溶性IL-2R測定試薬の基礎的検討

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<p>The levels of the soluble interleukin-2 receptor in serum are elevated in non-Hodgkin’s lymphoma and adult T-cell leukemia/lymphoma and reflect disease activity, so they are used for the assessment of treatment response, auxiliary diagnosis, and follow-up. Since the reagent “Lumipulse Presto IL-2R” that can be used with Lumipulse L2400 was developed this time, a basic study was carried out to introduce the reagent. Good results were obtained for within-run precision, between-day precision, dilution linearity, detection limit, and quantification limit. No effects of coexisting substances or container types were found. The correlation coefficient with “STACIA CLEIA IL-2R” was as high as 0.995, the regression equation was y = 1.17x − 34.33, and no extremely deviated sample was found. In conclusion, because of its good performance, it was suggested that the reagent can be introduced.</p>

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