Simulating Dictyostelium cell deformation in amoeboid movement

DOI 参考文献6件

書誌事項

公開日
2014-03-17
DOI
  • 10.15248/proc.1.25
公開者
The Institute of Electronics, Information and Communication Engineers

説明

A model system for propagating and spiral waves of phosphatidylinositol lipids observed in migrating Dictyostelium discoideum cell is proposed. In the model, chemical dynamics described by reaction-diffusion system is coupled with cell shape deformation represented by phase-field, which reproduces the excitability of the system and arising wave-wave and wave-cell boundary interactions. Parameter dependence of the model shows qualitative agreements with experimental perturbations, such as the loss of excitability by the excess actin in nullmutant of PIR. We also conducted non-parametric estimation of reaction diffusion equations that describe the observed spatio-temporal dynamics. In the method, Bayesian procedure for state-space model is performed by adopting a prior that assumes smooth functional form of reaction terms. Comparison of the results with the proposed mathematical model is discussed.

収録刊行物

  • IEICE Proceeding Series

    IEICE Proceeding Series 1 25-28, 2014-03-17

    The Institute of Electronics, Information and Communication Engineers

参考文献 (6)*注記

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詳細情報 詳細情報について

  • CRID
    1390565162127314432
  • DOI
    10.15248/proc.1.25
  • ISSN
    21885079
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

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