Exosome as a novel nanocarriers for therapeutic delivery

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  • Yoshioka Yusuke
    Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University
  • Ochiya Takahiro
    Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University

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Other Title
  • エクソソームによる新規DDSキャリアの開発
  • エクソソーム ニ ヨル シンキ DDS キャリア ノ カイハツ

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Abstract

Drug delivery system (DDS) is one of the key technologies to achieve safe treatment, as without DDS, drug molecules can easily diffuse throughout body and affect non-diseased sites. Exosomes serve as versatile intercellular communication vehicles and transfer their cargo to recipient cells. Therefore, increasing attention has been focused on exosome for the delivery of biomolecules and synthetic drugs to various target tissues. Although exosomes have been shown to harbor great promise in therapeutic delivery, substantial improvements regarding developing standardized isolation techniques with high efficiency and robust yield, scalable production methods, standard procedures for exosome storage, efficient loading methods that do not damage exosome integrity, and novel exosome-based nanocarriers and understanding their in vivo trafficking are still required before their clinical translation. In this chapter, we discuss the potential of exosome to be utilized as natural nanocarriers of functional small RNA, proteins, and synthetic drugs and compare their advantages and disadvantages to other delivery mechanisms.

Journal

  • Drug Delivery System

    Drug Delivery System 35 (1), 35-46, 2020-01-25

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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