Effect of Moisture Absorption on Tablet Surface Structure in Magnesium Oxide Tablets

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  • Matsuo Taisuke
    Division of Advanced Pharmaceutics, Department of Clinical Pharmaceutical Sciences, Iwate Medical University
  • Kasai Ryusei
    Division of Clinical Pharmaceutics and Pharmacy Practice, Department of Clinical Pharmacy, School of Pharmacy, Iwate Medical University
  • Arakawa Ryo
    The Nisshin OilliO Group, Ltd., Central Research Laboratory
  • Tairabune Tomohiko
    Division of Clinical Pharmaceutics and Pharmacy Practice, Department of Clinical Pharmacy, School of Pharmacy, Iwate Medical University Department of Pharmacy, Iwate Medical University Hospital
  • Sadzuka Yasuyuki
    Division of Advanced Pharmaceutics, Department of Clinical Pharmaceutical Sciences, Iwate Medical University
  • Kudo Kenzo
    Division of Clinical Pharmaceutics and Pharmacy Practice, Department of Clinical Pharmacy, School of Pharmacy, Iwate Medical University Department of Pharmacy, Iwate Medical University Hospital
  • Tomita Takashi
    Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Teikyo Heisei University

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Other Title
  • 崩壊時間の遅延をもたらす酸化マグネシウム錠の吸湿が錠剤の表面構造に及ぼす影響
  • ホウカイ ジカン ノ チエン オ モタラス サンカ マグネシウムジョウ ノ キュウシツ ガ ジョウザイ ノ ヒョウメン コウゾウ ニ オヨボス エイキョウ

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<p>Magnesium oxide tablets, which rapidly disintegrate, extend disintegration time upon moisture absorption. One of the reasons is thought that magnesium oxide causes the solid bridges between powder particles by moisture absorption. Tablets of pure magnesium oxide without additives changed tablet surface structure by moisture absorption. Although magnesium oxide tablets sold in clinical markets include various additives, the surface structures of the tablets have not been reported. In this paper, we found some relief structures in tablet surface of Magmitt® tablets which are one of the magnesium oxide tablets. It was thought that the relief structures increase contact area with the water, and related with fast disintegration in Magmitt® tablets. However, we revealed that the relief structures of Magmitt® tablets did not change when the disintegration time of the tablets extended by moisture absorption.</p>

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