Biofilm Formation by <i>Streptococcus mutans</i> is Enhanced by Indole via the Quorum Sensing Pathway
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- Inaba Tomohiro
- Environmental Management Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
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- Obana Nozomu
- Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba
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- Habe Hiroshi
- Environmental Management Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
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- Nomura Nobuhiko
- Faculty of Life and Environmental Sciences, University of Tsukuba
Bibliographic Information
- Other Title
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- Biofilm Formation by Streptococcus mutans is Enhanced by Indole via the Quorum Sensing Pathway
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Abstract
<p>Interspecies interactions among oral microorganisms in the pathogenic biofilms causing dental caries have not yet been elucidated in detail. We herein demonstrated that indole and its derivatives induced biofilm formation by Streptococcus mutans. Indole is an intercellular signaling molecule that is produced by oral bacteria other than S. mutans. The amounts of biofilm and extracellular DNA were significantly increased by the addition of indole and 4-hydroxyindole (4-HI). An examination with quorum sensing mutants showed that the induction of biofilm formation by indole and 4-HI required a quorum sensing system. These results suggest that this intercellular signaling molecule plays a role in pathogenic biofilm formation.</p>
Journal
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- Microbes and Environments
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Microbes and Environments 35 (2), n/a-, 2020
Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles
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Details 詳細情報について
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- CRID
- 1390566775131075712
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- NII Article ID
- 130007837477
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- NII Book ID
- AA11551577
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- ISSN
- 13474405
- 13426311
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- NDL BIB ID
- 030475417
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- PubMed
- 32350164
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed