Supplementation with geranylgeranoic acid during mating, pregnancy and lactation improves reproduction index in C3H/HeN mice

DOI Web Site Open Access
  • Tabata Yuki
    Molecular and Cellular Biology, Graduate School of Human Health Science, University of Nagasaki Nagayo
  • Uematsu Sayaka
    Molecular and Cellular Biology, Graduate School of Human Health Science, University of Nagasaki Nagayo
  • Shidoji Yoshihiro
    Molecular and Cellular Biology, Graduate School of Human Health Science, University of Nagasaki Nagayo

Bibliographic Information

Other Title
  • 交配期、妊娠期および授乳期におけるゲラニルゲラノイン酸の補給は C3H/HeN マウスの再生産指数を向上させる

Search this article

Abstract

<p><tt>Geranylgeranoic acid（GGA）, an acyclic retinoid of diterpenoid, is a natural compound found in some medicinal herbs such as turmeric. Our previous study demonstrated that oral supplementation of GGA during mating, pregnancy and lactation periods significantly increased the reproductive index（RI; the number of weaning pups divided by the number of mated couples）of AKR/J strain of mouse by 3 times compared to the non-supplemented control group. Here, we carried out the following experiments to confirm the GGA-mediated improvement of the RI by using C3H/HeN mice. At first, the mice were divided into 2 groups fed on either a commercial chow diet or supplemented with GGA（50 </tt>µ<tt>g/day）during a whole reproduction period. As a result, GGA supplementation increased the RI by 1.60±0.50 times compared to the control group. When the mice were supplemented with GGA only after mating（GGA was supplied only for pregnancy period, or only for gestation period）, their pregnancy rate declined. However, these two groups showed that their RIs were both higher than the control group, indicating that GGA supplementation helps to secure healthy pups after conception. Taken together with our previous finding, the present results strongly suggested that dietary supplementation of GGA during mating, gestational and lactating periods has potential </tt><tt>to upregulate RI in mammals.</tt></p>

Journal

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top