Drug-induced liver injury and disseminated intravascular coagulation syndrome caused by UFT prescribed as postoperative chemotherapy: Report of a case

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  • UFTの術後補助化学療法中に薬剤性肝障害と播種性血管内凝固症候群を発症した1例

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<p>Disseminated intravascular coagulation syndrome (DIC) is rare as a side effect of UFT therapy provided as postoperative chemotherapy for lung cancer. The present case was a 66-year-old man whose medical history only included a past infection of HBV. We performed right lower lobectomy with lymph node dissection by video-assisted thoracoscopic surgery for adenocarcinoma of right lung S6b and started UFT therapy one month after the surgery. However, the patient visited the hospital complaining of a fever and poor physical condition six weeks after starting UFT therapy, and was urgently hospitalized when liver injury was detected. We stopped UFT therapy and started the treatment for liver injury, but DIC developed on the next day. We therefore started thrombomodulin, after which his condition improved, and he was discharged 23 days after being admitted. In this case, because we did not detect any increase in the amount of HBV-DNA, we diagnosed him not with liver damage due to reactivation of HBV but with drug-induced liver injury due to UFT. While we tend to prescribe UFT for outpatients readily, we should observe patients' progress carefully for at least two months after starting therapy, as this treatment may cause drug-induced liver injury and DIC.</p>

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