Biological Studies on Mikamycin. IV Blood and Tissue Levels of Tritiated Mikamycins A and B
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- Tanaka Nobuo
- Institute of Applied Microbiology, University of Tokyo
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- Yamaguchi Hideyo
- Institute of Applied Microbiology, University of Tokyo
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- Umezawa Hamao
- Institute of Applied Microbiology, University of Tokyo
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説明
<p>Mikamycin, an antibiotic effective against gram-positive organisms including resistant staphylococci, exhibits a marked activity against experimental infections of staphylococci, hemolytic streptococci and pneumococci.1,2,3) It has been applied for clinical uses by a number of investigators and successful results have been accumulated. However there remains a discrepancy between a high in vivo activity and a low level in blood and tissues demonstrated by antimicrobial activity.1~4) For the purpose of investigating this problem, mikamycins A and B were labeled with tritium; and the blood concentration, tissue distribution, and renal and biliary excretion were observed. The results are presented in this paper.</p>
収録刊行物
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- The Journal of Antibiotics, Series A
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The Journal of Antibiotics, Series A 15 (1), 33-37, 1962
公益財団法人 日本感染症医薬品協会
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詳細情報 詳細情報について
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- CRID
- 1390566775150057600
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- NII論文ID
- 130007870803
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- ISSN
- 24355135
- 03681173
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可