PHEOCHROMOCYTOMA CRISIS WITH MIBG SCINTIGRAPHY NEGATIVE: A CASE REPORT

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  • Katsumata Yuki
    The Department of Urology, Yamagata Prefectural Central Hospital
  • Takai Yuki
    The Department of Urology, Yamagata Prefectural Central Hospital
  • Kuromoto Akito
    The Department of Urology, Yamagata Prefectural Central Hospital
  • Morozumi Kento
    The Department of Urology, Yamagata Prefectural Central Hospital
  • Hoshi Senji
    The Department of Urology, Yamagata Prefectural Central Hospital
  • Numahata Kenji
    The Department of Urology, Yamagata Prefectural Central Hospital
  • Sasano Kiminobu
    The Department of Pathology, Tohoku University School of Medicine

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Other Title
  • MIBGシンチグラフィ陰性褐色細胞腫クリーゼの一例

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<p>We report a case of pheochromocytoma crisis with negative MIBG scintigraphy. A 48-year-old man was admitted for hypertension crisis. Computed tomographic scan revealed a 60 mm right adrenal mass. The MIBG scintigraphy was negative, but we diagnosed pheochromocytoma crisis because of high blood catecholamine levels. We successfully managed the patient's hemodynamics through medical treatment and the patient was able to recover from the crisis. After appropriate preparation, the tumor was removed via laparotomy. SDHB mutation, related to the negative MIBG scintigraphy, was also denied pathologically by immunostaining procedures. Histopathologically, it showed a wide range of necrotic images. So the cause of the crisis was thought to be the release of a large amount of catecholamine from necrotic tumor cells. It was thought that scintigraphy became negative due to the decreased MIBG uptake of tumor cells with extensive necrosis.</p>

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