Two Cases of Radiation-induced Breast Angiosarcoma after Breast-conserving Surgery

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  • 乳房温存術後照射による放射線誘発性血管肉腫の2例
  • 症例 乳房温存術後照射による放射線誘発性血管肉腫の2例
  • ショウレイ チブサ オンゾン ジュツゴ ショウシャ ニ ヨル ホウシャセン ユウハツセイ ケッカン ニクシュ ノ 2レイ

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Abstract

<p>We encountered two cases of radiation-induced angiosarcoma after breast-conserving surgery (BCS), which is a rare disease with poor prognosis.</p><p>Case 1 : An 86-year-old woman was admitted to our hospital with a complaint of a lump and bleeding in the left chest. She had undergone BCS and received adjuvant radiotherapy for left breast cancer at the age of 79 years. She was diagnosed with recurrence based on core-needle biopsy. She was administered weekly PTX + bevacizumab. It was difficult to continue treatment due to adverse events ; hence, she underwent mastectomy with a wide range of skin resection of the breast. She was diagnosed with angiosarcoma. She developed local recurrence one month after her second surgery and died three months later.</p><p>Case 2 : A 67-year-old woman noted a skin eruption on the left side of her chest. She had undergone BCS and adjuvant radiotherapy after neoadjuvant chemotherapy for left breast cancer at the age of 61 years. She was diagnosed with angiosarcoma based on a skin biopsy. She also underwent surgery similar to the patient in Case 1. One year after her second surgery, she is alive without recurrence.</p>

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