Trial of tachyarrhythmia control by regional cooling of the heart

DOI
  • Seno Hiroshi
    Graduate School of Engineering, The University of Tokyo, Tokyo, Japan
  • Tomii Naoki
    Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
  • Yamazaki Masatoshi
    Graduate School of Engineering, The University of Tokyo, Tokyo, Japan
  • Honjo Haruo
    Research Institute of Environmental Medicine, Nagoya University, Aichi, Japan
  • Shibata Nitaro
    Shinjuku Mitsui Building Clinic, Tokyo, Japan
  • Sakuma Ichiro
    Graduate School of Engineering, The University of Tokyo, Tokyo, Japan

Bibliographic Information

Other Title
  • 心臓局所冷却による頻脈性不整脈制御の試み

Abstract

<p>【Background】Spiral Wave (SW) excitation, which is known to be a driving source of tachyarrhythmia, has been reported to move around the local cooling area of the heart. It may be possible to realize minimally invasive defibrillation, if the SW movement can be controlled by regional cooling. We proposed linear regional cooling (LRC) to stop SW excitation, and demonstrated the effectiveness of the method in in silico and ex vivo experiments. </p><p>【Methods】For the in silico experiment, we used a two-dimensional bidomain heart tissue model. Three LRC parameters were set: the angle of the cooling device with fiber orientation, the cooling device width and its cooling temperature. The dynamics of SW during LRC was simulated. We constructed a LRC system using low-temperature coolant, and ex vivo experiments were performed on extracted rabbit hearts. </p><p>【Results】As a result of the in silico experiment, effective SW movement was observed when LRC with low cooling temperature and wide cooling width was performed along the fiber orientation. In the ex vivo experiment, SW termination due to LRC was observed. </p><p>【Conclusion】It was shown that appropriate linear regional cooling could effectively terminate SW excitation.</p>

Journal

Details 詳細情報について

  • CRID
    1390566775157532544
  • NII Article ID
    130007884799
  • DOI
    10.11239/jsmbe.annual58.195
  • ISSN
    18814379
    1347443X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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