Photoelectric dye-coupled thin film induces light-evoked action potential spikes

DOI
  • Matsuo Toshihiko
    Okayama University Graduate School of Interdisciplinary Science and Engineering in Health Systems
  • Uchida Tetsuya
    Okayama University Graduate School of Natural Science and Technology

Bibliographic Information

Other Title
  • 光電変換色素結合薄膜型人工網膜によって誘起されるrd1マウス摘出変性網膜組織の活動電位スパイク

Description

<p>The multielectrode array system was used to record light-evoked action potential spikes in isolated degenerative retinal tissues to test the efficacy of photoelectric dye-coupled thin film retinal prosthesis, as a preclinical test for a medical device. Light-evoked action potential spike response was tested at first step in the isolated degenerative retinal tissue of retinal dystrophic rd1 mouse only on the multielectrode array, tested in the same retinal tissue overlain with a plain control film for light-off and light-on at second step, and tested in the same tissue overlain with a dye-coupled film at third step. The retinal tissues which showed light-evoked response at first or second step were not used for evaluation at third step. A step-by-step procedure with internal control was established to measure light-evoked action potential spikes by the multielectrode array in the isolated degenerative retinal tissue to evaluate photoelectric dye-coupled thin films.</p>

Journal

Details 詳細情報について

  • CRID
    1390566775157617920
  • NII Article ID
    130007884944
  • DOI
    10.11239/jsmbe.annual58.245
  • ISSN
    18814379
    1347443X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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