Development of pulsatile circulatory system for measuring ascending aorta hemodynamics with 4D-MRI

DOI
  • Nakama Natsuki
    Department of Integrative Bioscience and Biomeical Engineering, Graduate School of Advanced Science and Engineering , Waseda University, Tokyo, Japan
  • Hattori Kaoru
    Cooperative major in Advanced Biomedical Sciences, Graduate School of Advanced Science and Engineering , Waseda University, Tokyo, Japan Devision of Cardiovascular Surgery, Yamato Seiwa Hospital
  • Takada Junpei
    Department of Integrative Bioscience and Biomeical Engineering, Graduate School of Advanced Science and Engineering , Waseda University, Tokyo, Japan
  • Nishimura Gouki
    Department of Modern Mechanical Engineering, Graduate School of Creative Science and Engineering, Waseda University, Tokyo, Japan
  • Moriwaki Ryo
    Department of Modern Mechanical Engineering, Graduate School of Creative Science and Engineering, Waseda University, Tokyo, Japan
  • Kawasaki Eita
    Department of Integrative Bioscience and Biomeical Engineering, Graduate School of Advanced Science and Engineering , Waseda University, Tokyo, Japan
  • Nagao Mitunobu
    Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical University, Tokyo, Japan
  • Gotou Yasuhiro
    Department of Central Radiology, Tokyo Women's Medical University Hospital, Tokyo, Japan
  • Tsuboko Yusuke
    Waseda Research Institute for Science and Engineering, Waseda University, Tokyo, Japan
  • Iwasaki Kiyotaka
    Department of Integrative Bioscience and Biomeical Engineering, Graduate School of Advanced Science and Engineering , Waseda University, Tokyo, Japan Cooperative major in Advanced Biomedical Sciences, Graduate School of Advanced Science and Engineering , Waseda University, Tokyo, Japan Department of Modern Mechanical Engineering, Graduate School of Creative Science and Engineering, Waseda University, Tokyo, Japan Waseda Research Institute for Science and Engineering, Waseda University, Tokyo, Japan

Bibliographic Information

Other Title
  • 4D-MRI環境下での上行大動脈の血行動態計測を実現する拍動循環シミュレータの開発

Abstract

<p>Bicuspid aortic valve disease is a common congenital valvular disease. There are several variations in valve morphology and its relationship with ascending aortic dilation is not clear. In this study, we newly developed a pulsatile circulatory system to investigate flow in ascending aorta using 4D-MRI. The simulator consists of the silicone-made left ventricle, aortic valve chamber, aortic arch, compliance tank, and reservoir. The aortic valve model was fabricated using bovine aorta and pericardium and installed in the valve chamber. Pulsatile pressure and flow were pneumatically generated and controlled by peripheral resistive unit. A tricuspid aortic valve model was investigated by 4D-MRI. In the ascending aorta, straight flow was observed in early-systole and physiological clockwise-twisted flow was observed in late-systole respectively. Therefore, the pulsatile circulatory system developed in this study can be useful for revealing the relationship between bicuspid valve morphology and flow pattern in ascending aorta.</p>

Journal

Details

  • CRID
    1390566775157666688
  • NII Article ID
    130007885010
  • DOI
    10.11239/jsmbe.annual58.386
  • ISSN
    18814379
    1347443X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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