Towards the generation of human iPSC-derived hematopoietic stem cells
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- Abe Tomoyuki
- Open Science Laboratory, Center for Development of Advanced Medical Technology, Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University
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- Hanazono Yutaka
- Open Science Laboratory, Center for Development of Advanced Medical Technology, Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University
Bibliographic Information
- Other Title
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- ヒトiPS細胞由来造血幹細胞の作成を目指して
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Description
<p>Generation of hematopoietic stem cells (HSCs) from embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) has been a long-standing, challenging goal of hematology. In this review, current advances toward the goal utilizing various in-vitro differentiation techniques and animal in-vivo microenvironments will be summarized. In addition, we will introduce our unique method of sheep in-utero transplantation targeting a fetal liver as an in vivo microenvironment for hematopoietic engraftment.</p>
Journal
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- Organ Biology
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Organ Biology 27 (2), 167-172, 2020
The Japan Society for Organ Preservation and Biology
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Keywords
Details 詳細情報について
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- CRID
- 1390566775159802112
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- NII Article ID
- 130007888694
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- ISSN
- 21880204
- 13405152
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed