Efficacy of Pulmonary Artery Pulsatility Index as a Measure of Right Ventricular Dysfunction in Stable Phase of Dilated Cardiomyopathy

DOI Web Site Web Site PubMed 26 References
  • Kuwayama Tasuku
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Morimoto Ryota
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Oishi Hideo
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Kato Hiroo
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Kimura Yuki
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Kazama Shingo
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Shibata Naoki
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Arao Yoshihito
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Yamaguchi Shogo
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Hiraiwa Hiroaki
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Kondo Toru
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Furusawa Kenji
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Okumura Takahiro
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Murohara Toyoaki
    Department of Cardiology, Nagoya University Graduate School of Medicine

Search this article

Abstract

<p>Background:Right ventricular dysfunction (RVD) in the setting of left ventricular (LV) myocardial damage is a major cause of morbidity and mortality, and the pulmonary artery pulsatility index (PAPi) is a novel hemodynamic index shown to predict RVD in advanced heart failure. However, it is unknown whether PAPi can predict the long-term prognosis of dilated cardiomyopathy (DCM) even in the mild to moderate phase. This study aimed to assess the ability of PAPi to stratify DCM patients without severe symptoms.</p><p>Methods and Results:Between April 2000 and March 2018, a total of 162 DCM patients with stable symptoms were evaluated, including PAPi, and followed up for a median of 4.91 years. The mean age was 50.9±12.6 years and the mean LV ejection fraction (EF) was 30.5±8.3%. When divided into 2 groups based on median value of PAPi (low, L-PAPi [<3.06] and high, H-PAPi [≥3.06]), even though there were no differences in B-type natriuretic peptide or pulmonary vascular resistance, the probability of cardiac event survival was significantly higher in the L-PAP than in the H-PAP group by Kaplan-Meier analysis (P=0.018). Furthermore, Cox’s proportional hazard regression analysis revealed that PAPi was an independent predictor of cardiac events (hazard ratio: 0.782, P=0.010).</p><p>Conclusions:Even in patients identified with DCM in the mild to moderate phase, PAPi may help stratify DCM and predict cardiac events.</p>

Journal

  • Circulation Journal

    Circulation Journal 84 (9), 1536-1543, 2020-08-25

    The Japanese Circulation Society

References(26)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top