Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease

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  • Niida Yuki
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Masuda Masashi
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Adachi Yuichiro
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Yoshizawa Aika
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Ohminami Hirokazu
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Mori Yuki
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Ohnishi Kohta
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Yamanaka-Okumura Hisami
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Uchida Takayuki
    Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Nikawa Takeshi
    Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Yamamoto Hironori
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School Department of Health and Nutrition, Faculty of Human Life, Jin-ai University Department of Nephrology, Faculty of Medical Sciences, University of Fukui
  • Miyazaki Makoto
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver
  • Taketani Yutaka
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School

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<p>Skeletal muscle atrophy is associated with mortality and poor prognosis in patients with chronic kidney disease (CKD). However, underlying mechanism by which CKD causes muscle atrophy has not been completely understood. The quality of lipids (lipoquality), which is defined as the functional features of diverse lipid species, has recently been recognized as the pathology of various diseases. In this study, we investigated the roles of the stearoyl-CoA desaturase (SCD), which catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, in skeletal muscle on muscle atrophy in CKD model animals. In comparison to control rats, CKD rats decreased the SCD activity and its gene expression in atrophic gastrocnemius muscle. Next, oleic acid blocked the reduction of the thickness of C2C12 myotubes and the increase of the endoplasmic reticulum stress induced by SCD inhibitor. Furthermore, endoplasmic reticulum stress inhibitor ameliorated CKD-induced muscle atrophy (the weakness of grip strength and the decrease of muscle fiber size of gastrocnemius muscle) in mice and the reduction of the thickness of C2C12 myotubes by SCD inhibitor. These results suggest that the repression of SCD activity causes muscle atrophy through excessive endoplasmic reticulum stress in CKD.</p>

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