Development of a wearable pulse oximeter device measuring SpO2, heart rate and respiratory rate from conscious and unrestrained rats

DOI
  • OKUBO Yusuke
    Division of Cellular and Molecular Toxicology, Biological Safety and Research Center, National Institute of Health Sciences
  • KAMOTO Umihiro
    Department of Mechanical Engineering, Yokohama National University
  • TAQUAHASHI Yuhji
    Division of Cellular and Molecular Toxicology, Biological Safety and Research Center, National Institute of Health Sciences
  • KITAJIMA Satoshi
    Division of Cellular and Molecular Toxicology, Biological Safety and Research Center, National Institute of Health Sciences
  • OTA Hiroki
    Graduate School of System Integration, Yokohama National University

Bibliographic Information

Other Title
  • 覚醒下非拘束ラットから血中酸素飽和度・心拍数・呼吸数を計測可能なウエアラブルパルスオキシメーターの開発

Description

<p>In toxicity studies, one of the core endpoint is clinical observation including vital signs (VSs). Measurement of VSs over time has already been realized in safety pharmacology in drug development, but not in toxicity studies on general chemical substances. We believe that simple VSs measurement technique can achieve both refinement of toxicity evaluation and reduction of the number of animals. In this study, we developed a wearable pulse oximeter for rats to measure SpO2, heart rate and respiratory rate. We succeeded to measure these VSs from conscious and unrestrained rats.</p>

Journal

Details 詳細情報について

  • CRID
    1390567172568192512
  • NII Article ID
    130007898247
  • DOI
    10.14869/toxpt.47.1.0_o-4
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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