Comparison of acute inhalation toxicity of sulfuric acid between intratracheal instillation and whole-body inhalation

DOI

Bibliographic Information

Other Title
  • 気管内投与及び吸入曝露における硫酸の急性吸入毒性の比較

Description

<p>Intratracheal instillation (ITI) method is attracting attention as an alternative for aerosol inhalation toxicity test. In this study, the acute inhalation toxicity of sulfuric acid between ITI and whole-body inhalation was compared. Sulfuric acid was administered to rats by ITI. General condition and body weight were evaluated until 14 days after administration, and then pathological examination were conducted. LD50 of sulfuric acid by ITI was estimated to be 7 to 20 mg/kg. The acute inhalation toxicity by ITI was considered to more than twice as strong as that by whole-body inhalation.</p>

Journal

Details 詳細情報について

  • CRID
    1390567172568273792
  • NII Article ID
    130007898435
  • DOI
    10.14869/toxpt.47.1.0_p-224
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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