Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice

DOI
  • SAITO Hirokatsu
    Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences
  • HARA Kenshiro
    Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
  • TOMINAGA Takashi
    Laboratory for Neural Circuit Systems, Institute of Neuroscience, Tokushima Bunri University
  • NAKASHIMA Kinichi
    Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University
  • KITAJIMA Satoshi
    Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences
  • KANNO Jun
    National Institute of Health Sciences
  • TANEMURA Kentaro
    Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University

Bibliographic Information

Other Title
  • 低用量ペルメトリンの早期慢性ばく露による成熟後の雄マウス行動影響

Abstract

<p>Permethrin, a pyrethroid chemical, is widely used as a pesticide because of its rapid insecticidal activity. Although permethrin is considered to exert very low toxicity in mammals, the effects of early, low-level, chronic exposure on the adult central nervous system are unclear. In this study, we investigated the effects of low-level, chronic permethrin exposure in early life on the brain functions of adult mice, using environmentally relevant concentrations. We exposed mice to the acceptable daily intake level of permethrin (0.05 mg/kg/day) in drinking water during the prenatal and postnatal periods. We then examined the effects on the central nervous system in adult male offspring. In the permethrin exposure group, we detected behavior that displayed the impairment in learning and memory. Immunohistochemical analysis revealed an increase in doublecortin- (an immature neuron marker) positive cells in the hippocampal dentate gyrus in the permethrin exposure group compared with the control group. Additionally, in the permethrin exposure group there was a decrease in astrocyte number in the hilus of the dentate gyrus, and remaining astrocytes were often irregularly shaped. These results suggest that exposure to permethrin at low levels in early life affects the formation of the neural circuit base and behavior after maturation. Therefore, in the central nervous system of male mice, low‐level, chronic permethrin exposure during the prenatal and postnatal periods has effects that were not expected based on the known effects of permethrin exposure in mature animals.</p>

Journal

Details

  • CRID
    1390567172568312576
  • NII Article ID
    130007898356
  • DOI
    10.14869/toxpt.47.1.0_p-59e
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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