Analysis of the mechanism of proximal tubule S3 region-specific cytotoxicity to cisplatin

DOI
  • TAGUCHI Hiroki
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
  • NAKASONE Hiroki
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
  • FUJISHIRO Hitomi
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
  • SUMI Daigo
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
  • HIMENO Seiichiro
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

Bibliographic Information

Other Title
  • 白金錯化合物の近位尿細管部位特異的毒性の比較

Abstract

<p>Cisplatin (CDDP) is an anticancer drug that causes severe kidney damage, especially in the S3 region of the proximal tubule. We showed that cytotoxicity to CDDP, carboplatin (CAR), and oxaliplatin (OXA) is the highest in the S3-derived cells. The S3-specific toxicity could not be explained by accumulation of Pt. Since the highest amount of Pt uptake was found 15 minutes after the exposure, the cytotoxicity by 15 min-exposure to CDDP, CAR, and OXA was examined. As a result, even the 15-min exposure to these drugs caused the highest cytotoxicity in S3 cells, suggesting the importance of shout-term cellular responses.</p>

Journal

Details 詳細情報について

  • CRID
    1390567172568340864
  • NII Article ID
    130007898379
  • DOI
    10.14869/toxpt.47.1.0_p-44s
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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