Viral Etiology for Parkinson's Disease --A Possible Role of Influenza A Virus Infection
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- Takahashi Mitsuo
- Department of Internal Medicine and Health Care, School of Medicine, Fukuoka University, Japan
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- Yamada Tatsuo
- Department of Internal Medicine and Health Care, School of Medicine, Fukuoka University, Japan
書誌事項
- タイトル別名
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- Viral Etiology for Parkinson's Disease
- -A Possible Role of Influenza A Virus Infection-
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<p>Some clinical reports and epidemiological data suggest that a virus may play a role in the etiology of Parkinson's disease (PD). Once a certain strain of influenza A virus has adapted to the central nervous system, it will gain infectivity to neurons, especially in the substantia nigra, cerebellum and hippocampus, both in human cases and experimental models. Although efforts to detect virus particles in the brains, or antibodies in the serum or cerebrospinal fluid of patients with PD have been generally unsuccessful, recent immunohistochemical work has revealed the presence of complement proteins and the interferon induced MxA in association with Lewy bodies and swollen neuronal process. We propose a hypothesis that neurovirulent influenza A virus and other potent viruses may be responsible for the formation of Lewy bodies and the later death of nigral neurons, to constitute a viral etiology for PD.<tt> </tt></p>
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 52 (3), 89-98, 1999-08-30
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390567901488373120
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- NII論文ID
- 130007934505
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 4845802
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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