KB-R7943 Inhibits the Mitochondrial Ca<sup>2+</sup> Uniporter but Not Na<sup>+</sup>–Ca<sup>2+</sup> Exchanger in Cardiomyocyte-Derived H9c2 Cells

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  • Namekata Iyuki
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
  • Odaka Ryosuke
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
  • Hamaguchi Shogo
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
  • Tanaka Hikaru
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University

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  • KB-R7943 Inhibits the Mitochondrial Ca²⁺ Uniporter but Not Na⁺-Ca²⁺ Exchanger in Cardiomyocyte-Derived H9c2 Cells

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Abstract

<p>The effect of KB-R7943, an inhibitor of the plasmalemmal Na+–Ca2+ exchanger, on mitochondrial Ca2+ transporters was examined with membrane-permeabilized cardiomyocyte-derived H9c2 cells expressing the fluorescent Ca2+ indicator, yellow cameleon 3.1, in the mitochondria. KB-R7943, as well as ruthenium red, inhibited the rise in mitochondrial Ca2+ on increasing the extramitochondrial Ca2+ concentration from 0 nM to 300 nM. CGP-37157, but not KB-R7943, inhibited the decline in mitochondrial Ca2+on return to Ca2+ free extramitochondrial solution. These results indicated that KB-R7943 has inhibitory effects on the mitochondrial Ca2+ uniporter, but not on the mitochondrial Na+–Ca2+ exchanger.</p>

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