HHV-8-positive Castleman’s disease with rapidly progressing multiorgan failure mimicking TAFRO syndrome

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Other Title
  • TAFRO症候群の臨床所見を呈し急速に多臓器不全へ陥ったHHV-8陽性Castleman病
  • 症例報告 TAFRO症候群の臨床所見を呈し急速に多臓器不全へ陥ったHHV-8陽性Castleman病
  • ショウレイ ホウコク TAFRO ショウコウグン ノ リンショウ ショケン オ テイシ キュウソク ニ タゾウキ フゼン エ オチイッタ HHV-8 ヨウセイ Castlemanビョウ

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<p>A 60-year-old man was admitted to our hospital with multiple organ failure complicated by disseminated intravascular coagulation. He presented with thrombocytopenia, pleural effusion, ascites, high fever, and renal impairment, suggesting TAFRO syndrome. In addition to administering prednisolone, dialysis and mechanical ventilation were initiated for severe renal and respiratory insufficiencies, respectively. However, he died 5 days after admission. An autopsy was performed, resulting in the diagnosis of human herpesvirus (HHV)-8-positive plasma cell-type Castleman’s disease. Furthermore, HHV-8 was detected in the vascular endothelium and lymph nodes on immunohistochemical study. His rapidly deteriorating clinical course with the lack of serum hypergammaglobulinemia is atypical for Castleman’s disease. Therefore, HHV-8 may have incited the disorder’s aggressive behavior, causing TAFRO syndrome.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 61 (10), 1497-1501, 2020

    The Japanese Society of Hematology

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