A case of <i>MYCN</i>-amplified stage 4 neuroblastoma relapsed with catecholamine-negative tumor mainly composed of MIBG-non-avid component
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- Yaegashi Miki
- Department of Pediatric Oncology, Fukushima Medical University Hospital Department of Pediatrics, Fukushima Medical University
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- Sano Hideki
- Department of Pediatric Oncology, Fukushima Medical University Hospital
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- Takahashi Nobuhisa
- Department of Pediatric Oncology, Fukushima Medical University Hospital
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- Ohara Yoshihiro
- Department of Pediatric Oncology, Fukushima Medical University Hospital Department of Pediatrics, Fukushima Medical University
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- Kobayashi Shogo
- Department of Pediatric Oncology, Fukushima Medical University Hospital
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- Tanaka Hideaki
- Department of Pediatric Surgery, Fukushima Medical University
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- Shimizu Hirofumi
- Department of Pediatric Surgery, Fukushima Medical University
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- Hashimoto Yuko
- Department of Diagnostic Pathology, Fukushima Medical University
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- Mochizuki Kazuhiro
- Department of Pediatric Oncology, Fukushima Medical University Hospital
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- Hosoya Mitsuaki
- Department of Pediatrics, Fukushima Medical University
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- Kikuta Atsushi
- Department of Pediatric Oncology, Fukushima Medical University Hospital
Bibliographic Information
- Other Title
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- MIBG集積陰性成分を主体としたカテコラミン非産生の腫瘍が再発した<i>MYCN</i>増幅Stage4神経芽腫の1例
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Description
<p>We present a case of stage 4 neuroblastoma of the left adrenal gland with MYCN amplification in a 2.5-year-old boy. At the time of diagnosis, the tumor had a component that was partially negative for 123I-metaiodobenzylguanidine (MIBG) with MYCN amplification. Treatment was completed in accordance with the high-risk protocol, and complete remission was achieved. However, 14 months after treatment completion (at 4.5 years of age), the patient developed a facial nerve palsy. Cancer recurrence was observed in the left cerebellopontine angle, left orbital bone, and bone marrow. The recurrent lesion was weakly positive/negative for MIBG, the urinary catecholamine level was not elevated, and the bone marrow metastatic cells were negative for tyrosine hydroxylase. MIBG-non-avid neuroblastoma has a better prognosis than MIBG-avid neuroblastoma. However, among MIBG-non-avid tumors, non-catecholamine-secreting neuroblastomas have an increased likelihood of containing more undifferentiated and aggressive components and require caution for early relapse.</p>
Journal
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- The Japanese Journal of Pediatric Hematology / Oncology
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The Japanese Journal of Pediatric Hematology / Oncology 57 (3), 300-303, 2020
The Japanese Society of Pediatric Hematology / Oncology
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Keywords
Details 詳細情報について
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- CRID
- 1390567901495970048
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- NII Article ID
- 130007935407
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- ISSN
- 21895384
- 2187011X
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed