A Case of Anaphylaxis after First Ingestion of Soy protein Drink, Which in Considered Gly m 4 as the Major Causative Allergen

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  • HAMAOKA Dai
    Department of Dermatology, Hyogo Prefectural Kakogawa Medical Center
  • OTSUKA Haruhiko
    Department of Dermatology, Hyogo Prefectural Kakogawa Medical Center
  • YAMANO Nozomi
    Department of Dermatology, Hyogo Prefectural Kakogawa Medical Center
  • INOUE Yusuke
    Department of Dermatology, Hyogo Prefectural Kakogawa Medical Center
  • MORIYAMA Tatsuya
    Department of Applied Biological Chemistry, Faculty of Agriculture, Kindai University
  • ADACHI Atsuko
    Department of Dermatology, Hyogo Prefectural Kakogawa Medical Center

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Other Title
  • Gly m 4が主要原因アレルゲンと考えられた, ソイプロテイン飲料初回摂取後のアナフィラキシーの１例
  • 症例 Gly m 4が主要原因アレルゲンと考えられた,ソイプロテイン飲料初回摂取後のアナフィラキシーの1例
  • ショウレイ Gly m 4 ガ シュヨウ ゲンイン アレルゲン ト カンガエラレタ,ソイプロテイン インリョウ ショカイ セッシュ ゴ ノ アナフィラキシー ノ 1レイ

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<p>　Soy protein causes few cases of allergy at present even though several cases of soy milk allergy have been reported in Japan. However, with the spread of soy protein-containing foods, an increase in cases is expected. Here, we describe the case of a 44-year-old man showing anaphylactic symptoms including, facial edema, nasal obstruction, and dyspnea after his first intake of a soy protein drink. The patient had previously shown nasal obstruction after intake of soymilk and he had history of spring pollinosis. The skin prick test was positive for soy protein beverage and defatted soybean protein. The level of Gly m 4 specific IgE (CAP-FEIA) was 12.0 UA/ml. Based on the above results, we considered that Gly m 4 related Bet v 1 in the soy protein drink was the main antigen. Patients with pollinosis should be checked for specific IgE on birch and alder, and in the case of Gly m 4 positivity, the intake of soy protein-containing foods should be evaluated. Manufacturers should also alert the presence of soy protein for pollinosis patients.</p><p>(日本皮膚免疫アレルギー学会雑誌, 3 (3) : 436-442, 2020)</p>

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