Cytopathological findings of primary squamous cell carcinoma of the submandibular gland with intracytoplasmic vacuoles
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- KOSHIMIZU Chisa
- Department of Pathology, Kanazawa Medical University Hospital
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- OKANEMASA Yoshiiku
- Department of Pathology, Kanazawa Medical University Hospital
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- TERAUCHI Toshie
- Department of Pathology, Kanazawa Medical University Hospital
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- NAKANO Mariko
- Department of Pathology, Kanazawa Medical University Hospital
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- YAMASHITA Manabu
- Department of Pathology, Kanazawa Medical University Hospital
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- MIZUTANI Kenichi
- Department of Pathology, Kanazawa Medical University Hospital Department of Laboratory and Medicine, Kanazawa Medical University
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- SHIOYA Akihiro
- Department of Pathology, Kanazawa Medical University Hospital Department of Laboratory and Medicine, Kanazawa Medical University
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- KUROSE Nozomu
- Department of Pathology, Kanazawa Medical University Hospital Department of Laboratory and Medicine, Kanazawa Medical University
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- YAMADA Sohsuke
- Department of Pathology, Kanazawa Medical University Hospital Department of Laboratory and Medicine, Kanazawa Medical University
Bibliographic Information
- Other Title
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- 細胞質内空胞がみられた顎下腺原発扁平上皮癌の細胞学的所見
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Abstract
<p>Background : Primary squamous cell carcinoma of the salivary gland is extremely rare and is known to be associated with a very poor prognosis. Herein, we report the cytological features of a diagnostically difficult case of primary salivary gland squamous cell carcinoma with intracytoplasmic vacuoles, which resembled a mucoepidermoid carcinoma.</p><p>Case : A 65-year-old man presented to a physician with a swelling on the right mandible, which he had first noticed about a month earlier. Fine needle aspiration cytology revealed orange G-philic keratinized cells and strongly light green-stained cells in Papanicolaou stain, based on which the lesion was diagnosed as a squamous cell carcinoma. However, it was difficult to distinguish it from mucoepidermoid carcinoma because the tumor cells contained intracytoplasmic vacuoles. Histological examination showed moderately to poorly differentiated squamous cell carcinoma without any evidence of mucus production. Electron-microscopic examination of a formalin-fixed tissue specimen revealed dilated endoplasmic reticula, suggestive of intracytoplasmic vacuoles.</p><p>Conclusion : It is important to distinguish squamous cell carcinoma with intracytoplasmic vacuoles from mucoepidermoid carcinoma.</p>
Journal
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- The Journal of the Japanese Society of Clinical Cytology
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The Journal of the Japanese Society of Clinical Cytology 59 (6), 305-310, 2020
The Japanese Society of Clinical Cytology
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Details 詳細情報について
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- CRID
- 1390568456338901248
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- NII Article ID
- 130007959708
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- ISSN
- 18827233
- 03871193
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed