A case of anaphylaxis for nafamostat mesilate during hemodialysis leading to cardiac arrest.

DOI
  • Kato Fumito
    Center Hospital of the National Center for Global Health and Medicine (NCGM), Department of Emergency Medicine ＆ Critical Care
  • Sasaki Ryo
    Center Hospital of the National Center for Global Health and Medicine (NCGM), Department of Emergency Medicine ＆ Critical Care
  • Kobayashi Kentaro
    Center Hospital of the National Center for Global Health and Medicine (NCGM), Department of Emergency Medicine ＆ Critical Care
  • Uemura Tatsuki
    Center Hospital of the National Center for Global Health and Medicine (NCGM), Department of Emergency Medicine ＆ Critical Care
  • Matsuda Wataru
    Center Hospital of the National Center for Global Health and Medicine (NCGM), Department of Emergency Medicine ＆ Critical Care
  • Hirose Keika
    Center Hospital of the National Center for Global Health and Medicine (NCGM), Department of Emergency Medicine ＆ Critical Care
  • Yamamoto Makiko
    Center Hospital of the National Center for Global Health and Medicine (NCGM), Department of Emergency Medicine ＆ Critical Care
  • Otake Naruaki
    Center Hospital of the National Center for Global Health and Medicine (NCGM), Department of Emergency Medicine ＆ Critical Care
  • Shibasaki Takatoshi
    Center Hospital of the National Center for Global Health and Medicine (NCGM), Department of Emergency Medicine ＆ Critical Care
  • Kimura Akio
    Center Hospital of the National Center for Global Health and Medicine (NCGM), Department of Emergency Medicine ＆ Critical Care

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Other Title
  • 血液透析中の心停止の原因としてメシル酸ナファモスタットによるアナフィラキシーが疑われた1例

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Description

<p>Nafamostat mesilate (NM) has often been used as an anticoagulant for extracorporeal circulation in hemodialysis patients who have a high risk of bleeding. Reports of cardiac arrest caused by an allergic reaction to NM are rare. We report the case of a 70-year-old man who experienced NM-induced anaphylactic shock during hemodialysis, which resulted in cardiac arrest ; he did not have a rash. In patients receiving NM who experience cardiac arrest during hemodialysis, anaphylactic shock should be considered, regardless of the presence or absence of anaphylaxis-associated dermatological signs or a history of uneventful hemodialysis-related NM treatments.</p>

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