Microscopic Review on the Curability and Invasiveness of Heavy Ion Radiotherapy in a Patient with Locally Advanced High-grade Prostate Cancer without Biochemical Recurrence:

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  • 高悪性度・局所進行前立腺癌症例に対する重粒子線治療後の生化学的非再発例の剖検例
  • 高悪性度・局所進行前立腺癌症例に対する重粒子線治療後の生化学的非再発例の剖検例 : 特に前立腺および周囲組織の病理学的評価
  • コウアクセイド ・ キョクショ シンコウ ゼンリツセンガン ショウレイ ニ タイスル ジュウ リュウシセン チリョウ ゴ ノ セイカガクテキ ヒサイハツレイ ノ ボウケンレイ : トクニ ゼンリツセン オヨビ シュウイ ソシキ ノ ビョウリガクテキ ヒョウカ
  • The Initial Autopsy Case Report
  • - 特に前立腺および周囲組織の病理学的評価 -

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Abstract

<p>An 85-year-old men with a past history of locally advanced and high Gleason grade (4＋5) prostate cancer died suddenly. The autopsy confirmed that his direct cause of death was suffocation following aspiration pneumonia. He underwent definitive heavy ion radiotherapy in combination with one-year neoadjuvant and 1.5-year adjuvant combination androgen blockade (CAB) between 9 and 7 years before the sudden death and his PSA was stable at 0.04 ng/ml at one year before the death. Pathological findings confirmed that his prostate cancer was completely cured including surrounding tissues outside the prostate and there were no adverse pathological changes due to heavy ion radiation in the rectum and bladder neck. Many clinical studies have already confirmed heavy ion radiation therapy to be an effective and less invasive treatment for localized and locally advanced prostate cancer. This initial case report may further demonstrate both microscopic curability and safety of heavy ion radiation therapy.</p>

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